Background:

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

MAP4

Immunogen:

Fusion protein of human MAP4

Full name:

microtubule-associated protein 4

SwissProt:

P27816

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human ovarian cancer and human lung cancer

IHC Recommend dilution:

15-50