Background:

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

NAE1

Immunogen:

Fusion protein of human NAE1

Full name:

NEDD8 activating enzyme E1 subunit 1

Synonyms：

HPP1; ula-1; APPBP1; A-116A10.1

SwissProt:

Q13564

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human cervical cancer and human lung cancer

IHC Recommend dilution:

15-50