Background:

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

VPS37A

Immunogen:

Fusion protein of human VPS37A

Full name:

VPS37A subunit of ESCRT-I

Synonyms:

HCRP1; PQBP2; SPG53

SwissProt:

Q8NEZ2

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human prostate cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

44 kDa

WB Positive control:

Human bladder carcinoma and fetal liver tissue

WB Recommended dilution:

500-2000