Full name:

zinc finger CCCH-type and G-patch domain containing

Synonyms:

ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847

Swissprot:

Q8N5A5

Gene Accession:

BC019338

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.