Background:

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Applications:

WB

Name of antibody:

PKN1

Immunogen:

Synthesized peptide derived from Internal of human PKN1/PRK1.

Full name:

protein kinase N1

Synonyms：

DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA

SwissProt:

Q16512

WB Predicted band size:

104 kDa

WB Positive control:

Jurkat and Huvec cells lysates

WB Recommended dilution:

500-3000