Background:

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

NFKBIZ

Immunogen:

Synthetic peptide of human NFKBIZ

Full name:

NFKB inhibitor zeta

Synonyms:

IKBZ; INAP; MAIL

SwissProt:

Q9BYH8

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

78 kDa

WB Positive control:

293T cell lysate

WB Recommended dilution:

500-2000