Background:

This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Applications:

ELISA, IHC

Name of antibody:

POT1

Immunogen:

Fusion protein of human POT1

Full name:

protection of telomeres 1

Synonyms:

CMM10; HPOT1

SwissProt:

Q9NUX5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human esophagus cancer

IHC Recommend dilution:

25-100