Background:

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Applications:

ELISA, WB, IHC

Name of antibody:

MTA2

Immunogen:

Synthetic peptide of human MTA2

Full name:

metastasis associated 1 family member 2

Synonyms:

PID; MTA1L1

SwissProt:

O94776

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

75 kDa

WB Positive control:

NIH/3T3，A431，293T and Hela cell lysates

WB Recommended dilution:

500-2000