Background:

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

MRPL48

Immunogen:

Fusion protein of human MRPL48

Full name:

mitochondrial ribosomal protein L48

Synonyms:

L48MT; CGI-118; HSPC290; MRP-L48

SwissProt:

Q96GC5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human gastric cancer

IHC Recommend dilution:

150-300