Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.

Applications:

ELISA, IHC

Name of antibody:

MMP2

Immunogen:

Synthetic peptide of human MMP2

Full name:

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Synonyms:

CLG4; MONA; CLG4A; TBE-1; MMP-II

SwissProt:

P08253

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

25-100