Background:

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.

Applications:

IHC

Name of antibody:

PIK3R5

Immunogen:

Synthesized peptide derived from internal of human PIK3R5.

Full name:

phosphoinositide-3-kinase, regulatory subunit 5

Synonyms：

p101; FOAP-2; P101-PI3K; F730038I15Rik

SwissProt:

Q8WYR1

IHC positive control:

Human colon carcinoma tissue

IHC Recommend dilution:

50-100