Background:

This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene.

Applications:

ELISA, IHC

Name of antibody:

STAM

Immunogen:

Fusion protein of human STAM

Full name:

signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Synonyms:

STAM1; STAM-1

SwissProt:

Q92783

IHC positive control:

Human gastric cancer and human esophagus cancer

IHC Recommend dilution:

50-200