Background:

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

Applications:

ELISA, WB, IHC

Name of antibody:

PLAUR

Immunogen:

Fusion protein of human PLAUR

Full name:

Plasminogen activator, urokinase receptor

Synonyms：

CD87; UPAR; URKR; U-PAR

SwissProt:

Q03405

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lung cancer and Human colon cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

37 kDa

WB Positive control:

A549 cells

WB Recommended dilution:

500-2000