Background:

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Applications:

ELISA, WB, IHC

Name of antibody:

PLA2G4A

Immunogen:

Fusion protein of human PLA2G4A

Full name:

phospholipase A2, group IVA (cytosolic, calcium-dependent)

Synonyms：

PLA2G4; cPLA2-alpha

SwissProt:

P47712

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human brain

IHC Recommend dilution:

50-200

WB Predicted band size:

85 kDa

WB Positive control:

293T cells

WB Recommended dilution:

500-2000