Background:

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

NDRG1

Immunogen:

Synthetic peptide of human NDRG1

Full name:

N-myc downstream regulated 1

Synonyms：

GC4, RTP, DRG1, NDR1, NMSL, TDD5, CAP43, CMT4D, DRG-1, HMSNL, RIT42, TARG1, PROXY1

SwissProt:

Q92597

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human brain and Human esophagus cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

43 kDa

WB Positive control:

Human lymphoma tissue

WB Recommended dilution:

500-2000