Background:

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module.

Applications:

IHC

Name of antibody:

PRKCZ(Phospho-Thr410)

Immunogen:

Peptide sequence around phosphorylation site of threonine 410(T-S-T(p)-F-C) derived from Human PKCζ.

Full name:

protein kinase C, zeta

Synonyms：

PKC2; PKC-ZETA

SwissProt:

Q05513

IHC positive control:

Human lung carcinoma tissue

IHC Recommend dilution:

50-100