Background:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

NTRK2

Immunogen:

Fusion protein of human NTRK2

Full name:

neurotrophic receptor tyrosine kinase 2

Synonyms:

TRKB; trk-B; GP145-TrkB

SwissProt:

Q16620

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

20-100