Background:

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Applications:

ELISA, WB, IHC

Name of antibody:

NQO1

Immunogen:

Synthetic peptide of human NQO1

Full name:

NAD(P)H dehydrogenase, quinone 1

Synonyms:

DTD, QR1, DHQU, DIA4, NMOR1, NMORI

SwissProt:

P15559

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human liver cancer and Human ovarian cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

31 kDa

WB Positive control:

Hela cells

WB Recommended dilution:

500-2000