Background:

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Applications:

WB, IHC

Name of antibody:

PARK2

Immunogen:

Synthesized peptide derived from human Parkin antibody.

Full name:

parkin RBR E3 ubiquitin protein ligase

Synonyms：

PDJ; PRKN; AR-JP; LPRS2

SwissProt:

O60260

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

52 kDa

WB Positive control:

Jurkatcells lysate

WB Recommended dilution:

500-3000