Background:

This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

RBFOX2

Immunogen:

Fusion protein of human RBFOX2

Full name:

RNA binding fox-1 homolog 2

Synonyms:

RTA; fxh; FOX2; RBM9; Fox-2; HNRBP2; HRNBP2; dJ106I20.3

SwissProt:

O43251

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer

IHC Recommend dilution:

50-300