Background:

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Applications:

WB

Name of antibody:

NUMBL

Immunogen:

Fusion protein of human NUMBL

Full name:

NUMB like endocytic adaptor protein

Synonyms:

NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE

SwissProt:

Q9Y6R0

WB Predicted band size:

65 kDa

WB Positive control:

Kidney tissue

WB Recommended dilution:

500-2000