Background:

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology.

Applications:

ELISA, WB, IHC

Name of antibody:

MRPL11

Immunogen:

Fusion protein of human MRPL11

Full name:

mitochondrial ribosomal protein L11

Synonyms：

L11MT; CGI-113; MRP-L11

SwissProt:

Q9Y3B7

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human liver cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

21 kDa

WB Positive control:

Hela, hepg2, lncap, K562, Jurkat and A549 cells

WB Recommended dilution:

500-2000