Background:

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

Applications:

WB

Name of antibody:

PAK2(Ab-141)

Immunogen:

Synthesized non-phosphopeptide derived from human PAK2 around the phosphorylation site of serine 141 (Y-L-S(p)-F-T).

Full name:

p21 protein (Cdc42/Rac)-activated kinase 2

Synonyms：

PAK65; PAKgamma

SwissProt:

Q13177

WB Predicted band size:

58 kDa

WB Positive control:

Hela cells treated with TSA (400nM, 24hours) lysate

WB Recommended dilution:

500-3000