Background:

Activating signal co-integrator-1 (ASC-1), originally identified as TRIP4, is a transcriptional co-activator of nuclear receptors that associates with specific components of the RNA polymerase II complex and binds the basal transcription factors TBP and TFIIA. ASC-1 functions with the transcription integrators SRC-1 and CBP/p300 through its zinc finger motif and is dependent on their ligand-dependent transactivation domain, AF2. Endogenous ASC-1 in HeLa cells is predominantly a nuclear protein. Under conditions of serum starvation, ASC-1 localizes to the cytoplasm.

Applications:

ELISA, IHC

Name of antibody:

TRIP4

Immunogen:

Fusion protein of human TRIP4

Full name:

thyroid hormone receptor interactor 4

Synonyms：

ASC1; ASC-1; HsT17391

SwissProt:

Q15650

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human liver cancer and human gastric cancer

IHC Recommend dilution:

50-200