Background:

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Applications:

ELISA, IHC

Name of antibody:

PRKAA2

Immunogen:

Fusion protein of human PRKAA2

Full name:

protein kinase, AMP-activated, alpha 2 catalytic subunit

Synonyms：

AMPK; AMPK2; PRKAA; AMPKa2

SwissProt:

P54646

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and human thyroid cancer

IHC Recommend dilution:

25-100